Population Genomics: Ageing by Association
نویسندگان
چکیده
Mutations in the gene Klotho lead to premature ageing in mice. Recent work on human genetic variation has identified an association between a particular allele of Klotho and human lifespan. A harbinger of things to come, this work illustrates the power and growth potential for association studies of human ageing.
منابع مشابه
Predictors of Healthcare Expenditure: Aging, Disability or Development?
Objective: Studies show that almost every country across the world will experience a remarkable increase in their healthcare costs and ageing population by 2030. Also, people with disabilities are more likely to impose considerable healthcare costs on families and governments than their counterparts. On the other hand, socioeconomic status of countries can be an important factor to predict heal...
متن کاملGenetics and genomics of human ageing.
Ageing in humans is typified by the decline of physiological functions in various organs and tissues leading to an increased probability of death. Some individuals delay, escape or survive much of this age-related decline and live past age 100. Studies comparing centenarians to average-aged individuals have found polymorphisms in genes that are associated with long life, including APOE and FOXO...
متن کاملRural Ageing: Iran is on the Brink of a New Social Problem
The paper aims to examine the population ageing as a new phenomenon effecting rural areas in Iran. Population ageing is going up throughout the country especially in the rural areas by 6.8 percent. fertility decline, increase in the youth migration to cities, and coming back to rural areas after retiring are the major factors which involve in rural ageing. This may jeopardize the communities. f...
متن کاملBeyond the evolutionary theory of ageing, from functional genomics to evo-gero.
By the mid 1970s, the mechanisms by which ageing can evolve had a secure theoretical basis in population genetics. Here, we discuss how subsequent evolutionary work has focussed on testing and extending this theory, and on attempting to integrate it with other emerging facets of the biology of ageing, such as genetic studies of long-lived mutants and of phenotypic plasticity in ageing, such as ...
متن کاملThe Future of Ageing and Its Health Care Costs: A Warning for Health System
This article is focused on ageing and the rapid ageing population growth, from future health care costs prospectus. It reviews ageing population statistics in several courtiers as well as Iran, to illustrate the significance of the ageing population growth in the next decades. Nevertheless, the health care costs for elderly people are described and the considerable differences between health ca...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002